KPDS ÜDS OKUMA PARÇASI - 11

For years, it has been assumed that obesity is the result of "too much food and too little exercise". While this maxim is largely correct, the etiology of obesity can be much more complex. There is a well-documented familial tendency, but whether this is of environmental or genetic origin is unclear. Studies of twins separated at birth and living apart provide strong evidence for a substantial genetic influence. Children of overweight parents, when adopted by "lean" families, have a greater tendency to become obese than do adoptees from nonobese natural parents. "Energy efficiency" may contribute to obesity; with reserves of fat deposits readily available to metabolize in the obese, a given amount of activity requires a smaller expenditure of energy. This theory has been invoked by those who complain that they "gain weight whether they eat or not", and indeed there is evidence of differences in energy efficiency among individuals. Similarly, obesity has been attributed to abnormally low basal metabolic rates (BMRs) since obese individuals do show lower BMRs. However, this fact is due to an artifact of BMP measurement; a larger proportion of the total fat mass of an obese person is inert, low-metabolizing fat, a fact that makes BMR calculations lower.